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SMAD anchor for receptor activation : ウィキペディア英語版 | Zinc finger FYVE domain-containing protein 9
Zinc finger FYVE domain-containing protein 9 or SARA (SMAD anchor for receptor activation) is a protein that in humans is encoded by the ''ZFYVE9'' gene. SARA contains a double zinc finger (FYVE domain). SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the R-SMADs SMAD2 and SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as transcription factors. ==References==
抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)』 ■ウィキペディアで「Zinc finger FYVE domain-containing protein 9」の詳細全文を読む
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